Massage a pea-sized dab into the skin and apply to targeted areas, 1-2 times daily. Adjust the amount as needed. It does not take much to tackle a large area such a shoulder blade or hip flexor. The cream is a topical and will not absorb into the bloodstream, but will absorb directly into the tissue. You will notice the fast-acting relief in this quickly absorbing cream. An all-day relief is the goal, if you find yourself applying more than once a day, try the Full Spectrum 1000mg Flower Power.